Description The ICRANet-Isfahan Astronomy Meeting : From Ancient Persian Astronomy to Recent Developments in Theoretical and Experimental Physics, Astrophysics and General Relativity, was held in November 2021 and was organised by Isfahan University of Technology (IUT) and the International Center for Relativistic Astrophysics Network (ICRANet). The meeting provided opportunities for new collaborations and studies ranging from historical aspects of ancient Persian astronomy to recent developments in observational astronomy and high energy astrophysical phenomena. This multiauthor volumes publishes the proceedings including presentations on Gamma-ray Bursts (GRBs), Active Galactic Nuclei (AGNs), Black Holes, Supernovae, General Relativity and its mathematical foundations, Theories of Gravity, Dark Matter and Early Universe Cosmology.